Diverse Venom Array
A diverse venom array is ideal for those projects or targets where there are no known venom leads and where a targeted approach is too risky. Each venom contains several hundred different components. Deconvolution takes longer, but still delivers useful tools for novel targets.
Description
Our Diverse Venom Array consists of 30 crude venoms in triplicate, from a phylogenetically and geographically diverse set of species. These venoms are selected to maximise potential hit on novel targets. As venom evolved independently in snakes, scorpions, spiders and centipedes, there is a large diversity of molecular classes and also within groups. We include species from different continents and from different habitats, which powers natural selection in different ways.
This product is used as a pre-screen to inform the design of a Targeted Venom Discovery Array™ (T-VDA™). T-VDAs use fractionated venoms to find closely related hits for potential structure-activity relationship studies.
Example Plate Layout (1 mg/well)
Diverse Venom Array Species List
| Code | Species | Group | Family/sub-family |
|---|---|---|---|
| S.har | Scolopendra hardwickei | Centipede | Scolopendridae |
| A.aus | Androctonus australis | Scorpion | Buthidae |
| P.lio | Parabuthus liosoma | Scorpion | Buthidae |
| H.ari | Hadrurus arizonensis | Scorpion | Caraboctonidae |
| H.pau | Hadogenes paucidens | Scorpion | Hemiscorpiidae |
| P.kra | Protoiurus Kraepelini | Scorpion | Iuridae |
| H.swa | Heterometrus swammerdami | Scorpion | Scorpionidae |
| O.scc | Oxyuranus scutellatus canni | Snake (taipan) | Elapinae |
| N.mel | Naja melanoleuca | Snake (cobra) | Elapinae |
| N.nig | Naja nigricollis | Snake (cobra) | Elapinae |
| N.sia | Naja siamensis | Snake (cobra) | Elapinae |
| D.pol | Dendroaspis polylepis | Snake (mamba) | Elapinae |
| D.ang | Dendroaspis angusticeps | Snake (mamba) | Elapinae |
| C.rho | Calloselasma rhodostoma | Snake (pit viper) | Crotalinae |
| C.atr | Crotalus atrox | Snake (pit viper) | Crotalinae |
| C.rru | Crotalus ruber | Snake (pit viper) | Crotalinae |
| S.mil | Sistrurus miliarius barbouri | Snake (pit viper) | Crotalinae |
| T.vog | Trimeresurus vogeli | Snake (pit viper) | Crotalinae |
| M.xan | Montivipera xanthina | Snake (viper) | Viperinae |
| B.grh | Bitis gabonica rhinoceros | Snake (viper) | Viperinae |
| A.met | Avicularia metallica | Theraphosid | Aviculariinae |
| T.cup | Tapinauchenius cupreus | Theraphosid | Aviculariinae |
| E.pac | Eucratoscelus pachypus | Theraphosid | Eumenophorinae |
| P.lug | Pterinochilus lugardi | Theraphosid | Harpactirinae |
| H.lbo | Cyriopagopus albostriatum | Theraphosid | Ornithoctoninae |
| P.for | Poecilotheria formosa | Theraphosid | Poecilotheriinae |
| P.cam | Psalmopoeus cambridgei | Theraphosid | Selenocosmiinae |
| H.mac | Heteroscodra maculata | Theraphosid | Stromatopelminae |
| A.cor | Acanthoscurria cordubensis | Theraphosid | Theraphosinae |
| T.str | Theraphosa stirmi | Theraphosid | Theraphosinae |