Our T-VDAs are specifically designed to find effective hits for your specific targets. This means they deliver the greatest value for a new lead material, from specially selected venom components that have been purified and standardised in 384 well plates. We have separated the majority of the competing venom components through multidimensional HPLC to produce clear data of activity against the target of choice.
We use a wide range of venoms from snakes, scorpions, tarantulas, true spiders and other species, selected according to each specific target. Our T-VDAs are formatted to maximise the likelihood of success for difficult targets and new mechanisms of action. These products can be used for research applications, including target identification, screening, processing and validation, and for proof of concept and proof of mechanism studies.
• Venom from 12 species
• 2D HPLC fractionation
• Supplied freeze-dried in Echo qualified 384 plates
• 1-5 peptides per well
• 3-5 replicates per well
We also offer full follow-up services, including hit identification, structure-activity relationships and bulk resupply.
With the huge array of drug discovery, and crop science targets with us, it is easy for our customers to develop novel ligands and tools for targets which have not yet been discovered. We offer a custom array design service, using our expertise in combination with databases and published literature to produce T-VDAs for novel targets. Many of these custom arrays perform so well that they later become standard T-VDAs.
This custom service has lead us into novel venom pharmacology such as interactions with epigenetic targets including S100 and bromodomains, but also glutamate transporters and others.
We will often source new species to add to our collection whenever possible. We can even include customer’s own preferred species, provided that they can be obtained in a way that is compliant with the Nagoya Protocol.
We offer tailor-made arrays of 1D or 2D HPLC fractionated venoms, that are manufactured specifically to meet your needs. Our venom experts can offer detailed guidance on choosing any 12 species as needed to optimally hit your target of interest. For further information, or for an informal discussion, contact a member of our team today.