Cosmetic Peptides

Scientific Posters

Identification of novel scorpion venom peptide inhibitors of the Kv1.3 ion channel and their potential as drug discovery leads for human T-cell mediated disease

Kirby, R.W., Tang, R., Witton, I., Webdale, L., Baker, S., Knight, E., Trim, S.A. & Rogers, R.
ELRIG Drug Discovery 2018

Investigating the effects of Naja nigricollis venom on colorectal and pancreatic cancer cell lines

Farooq, I., Trim, S.A., Knight, E.L. & Trim, C.M.
Canterbury Christ Church University Symposium 2018

Investigation of the antibacterial activity of venoms against Staphylococcus aureus

Hegerova, L., Trim, S.A. & Byrne, L.
Canterbury Christ Church University Symposium 2018

Naja nigricollis Venom Exosomes Biological Functions and Interactions

Lundin, A., Trim, S.A., Trim, C.M. & Wilson, C.
Canterbury Christ Church University Symposium 2018

Improving GFP production utilising venom components to enhance transfection efficiency in Cos 7 cells

Roznovcova, M., Trim, S.A. & Trim, C.M.
Canterbury Christ Church University Symposium 2018

Activating challenging GPCRs with venom peptides

Williamson, H.K., Bennett, N. & Walsh, J.
ELRIG Drug Discovery 2017

Identification of Cobra Venom Actives as Potential Novel Pancreatic Cancer Therapeutics

Knight, E.L., Trim, S.A. & Trim, C.M.
Cambridge Pancreatic Cancer Symposium 2017

Evaluation of venoms as a source of novel ligands for drug discovery

Plant, H., Stacey, C., Wigglesworh, M., & Sinclair, I.
ELRIG Drug Discovery 2016

The antimicrobial effects of animal venom

Wyles, J., Bendo, M., Hale, G., Holmes, H., Trim, S.A. & Trim, C.M.
ELRIG Drug Discovery 2016

Targeting Breast Cancer Signalling Pathways with Animal Venoms

McCullough, D., Atofanei, C., Knight, E., Trim, S.A. & Trim, C.M.
ELRIG Drug Discovery 2016

Novel haemoglobin modifying activity discovered through screening T-VDACV

Hayter, P., Datwani, S., Ellson, R., Croucher, L., Wark, C., Baines, A., & Trim, S.A.
ELRIG Drug Discovery 2013

Characterisation of Novel African Diplopod Defensive Fluids

Trim, C.M. & Trim, S.A.
International Society of Toxinology European Meeting, 2011

Safe laboratory management for true spiders (Araneomorphae) of medical importance

Reed, S.E., Lock, M.M.G & Trim, S.A.
LASA winter meeting 2010

Scientific Papers

Impact of Naja nigricollis Venom on the Production of Methaemoglobin

Williams, H.F., Hayter, P., Ravishankar, D., Baines, A., Layfield, H.J., Croucher, L., Wark, C., Bicknell, A.B., Trim, S., & Vaiyapuri, S. (2018)
Toxins. 10 (12)

Tarantula husbandry and critical care

Pellett, S., Bushell, M. and Trim, S.A. (2015)
Companion Animal. 20 (2)

Venom: the sharp end of pain therapeutics

Trim, S.A. and Trim, C.M. (2013)
British Journal of Pain. 7 (4)

Refining laboratory husbandry of venomous snakes of the family Elapidae

Loaring, C. and Trim, S.A.
Animal Technology and Welfare, December 2012

Laboratory husbandry of arboreal tarantulas (Theraphosidae) and evaluation of environmental enrichment

Bennie, M.G., Loaring, C. and Trim, S.A.
Animal Technology and Welfare, December 2011

Safe laboratory management for arachnids of medical importance

Reed, S.E., Lock, M.G. and Trim, S.A.
Animal Technology and Welfare, August 2011

White Papers

Reviews and Scientific Papers

A New Topical Eye Drop Containing LyeTxI-b, a Synthetic Peptide Designed from a Lycosa erithrognata Venom Toxin, Was Effective to Treat Resistant Bacterial Keratitis.

Silva C.N.D., Silva F.R.D., Dourado L.F.N., Reis P.V.M.D., Silva R.O., Costa B.L.D., Nunes P.S., Amaral F.A., Santos V.L.D., de Lima M.E. & Silva Cunha Júnior A.D. (2019) Toxins (Basel). 11 (4)

Peptidomic characterization and bioactivity of Protoiurus kraepelini (Scorpiones: Iuridae) venom.

Somay Doğan T., Iğci N., Biber A., Gerekçi S., Hüsnügil H.H., Izbirak A. & Özen C. (2018) Turk J Biol. 42: 490-497.

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

Chassagnon, I.R., McCarthy, C.A., Chin, Y.K.-Y., Pineda, S.S., Keramidas, A., Mobli, M., Pham, V., De Silva, T.M., Lynch, J.W., Widdop, R.E., Rash, L.D. & King, G.F. (2017). Proceedings of the National Academy of Sciences of the United States of America 114: 143750-3755.

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.

Osteen, J.D., Herzig, V., Gilchrist, J., J. Emrick, J.J., Zhang, C., Wang, X., Castro, J., Garcia-Caraballo, S., Grundy, L., Rychkov, G.Y, Weyer, A.D., Dekan, Z., Undheim, E.A.B., Alewood, P., Stucky, C.L., Brierley, S.M., Basbaum, A.I., Bosmans, F., King, G.F. & Julius, D. (2016). Nature 534: 494–499

Peptide therapeutics: current status and future directions.

Fosgerau, K. and Hoffmann, T. (2015). Drug Discovery Today 20 (1):122-128.

Isolation of an Orally Active Insecticidal Toxin from the Venom of an Australian Tarantula

Hardy, M.C., Daly, N.L., Mobli, M., Morales, R.A.V. & King, G.F. (2013). PLoS ONE, 8 (9)

Scorpion venom components that affect ion-channels function.

Quintero-Hernández, V., Jiménez-Vargas, J.M., Gurrola, G.B., Valdivia, H.H. & Possani, L.D. (2013). Toxicon 76: 328-342

Black mamba venom peptides target acid-sensing ion channels to abolish pain

Diochot, S., Baron, A., Salinas, M., Douguet, D., Scarzello, S., Dabert-Gay, A.S., Debayle, D., Friend, V., Alloui, A., Lazdunski, M., Lingueglia, E. (2012). Nature, 490 (7421)

Use of Venom Peptides to Probe Ion Channel Structure and Function.

Dutertre, S. and Lewis, R.J. (2010). Journal of Biological Chemistry 285: 13315-13320.